diff --git a/src/dynarmic/backend/x64/emit_x64_vector.cpp b/src/dynarmic/backend/x64/emit_x64_vector.cpp
index 871aa2e4..6b1549c1 100644
--- a/src/dynarmic/backend/x64/emit_x64_vector.cpp
+++ b/src/dynarmic/backend/x64/emit_x64_vector.cpp
@@ -439,6 +439,17 @@ void EmitX64::EmitVectorAnd(EmitContext& ctx, IR::Inst* inst) {
     EmitVectorOperation(code, ctx, inst, &Xbyak::CodeGenerator::pand);
 }
 
+void EmitX64::EmitVectorAndNot(EmitContext& ctx, IR::Inst* inst) {
+    auto args = ctx.reg_alloc.GetArgumentInfo(inst);
+
+    const Xbyak::Xmm xmm_a = ctx.reg_alloc.UseXmm(args[0]);
+    const Xbyak::Xmm xmm_b = ctx.reg_alloc.UseScratchXmm(args[1]);
+
+    code.pandn(xmm_b, xmm_a);
+
+    ctx.reg_alloc.DefineValue(inst, xmm_b);
+}
+
 static void ArithmeticShiftRightByte(EmitContext& ctx, BlockOfCode& code, const Xbyak::Xmm& result, u8 shift_amount) {
     if (code.HasHostFeature(HostFeature::GFNI)) {
         const u64 shift_matrix = shift_amount < 8
diff --git a/src/dynarmic/frontend/A32/translate/impl/asimd_three_regs.cpp b/src/dynarmic/frontend/A32/translate/impl/asimd_three_regs.cpp
index 49a655c0..dd485a63 100644
--- a/src/dynarmic/frontend/A32/translate/impl/asimd_three_regs.cpp
+++ b/src/dynarmic/frontend/A32/translate/impl/asimd_three_regs.cpp
@@ -318,7 +318,7 @@ bool TranslatorVisitor::asimd_VAND_reg(bool D, size_t Vn, size_t Vd, bool N, boo
 
 bool TranslatorVisitor::asimd_VBIC_reg(bool D, size_t Vn, size_t Vd, bool N, bool Q, bool M, size_t Vm) {
     return BitwiseInstruction<false>(*this, D, Vn, Vd, N, Q, M, Vm, [this](const auto& reg_n, const auto& reg_m) {
-        return ir.VectorAnd(reg_n, ir.VectorNot(reg_m));
+        return ir.VectorAndNot(reg_n, reg_m);
     });
 }
 
@@ -342,19 +342,19 @@ bool TranslatorVisitor::asimd_VEOR_reg(bool D, size_t Vn, size_t Vd, bool N, boo
 
 bool TranslatorVisitor::asimd_VBSL(bool D, size_t Vn, size_t Vd, bool N, bool Q, bool M, size_t Vm) {
     return BitwiseInstruction<true>(*this, D, Vn, Vd, N, Q, M, Vm, [this](const auto& reg_d, const auto& reg_n, const auto& reg_m) {
-        return ir.VectorOr(ir.VectorAnd(reg_n, reg_d), ir.VectorAnd(reg_m, ir.VectorNot(reg_d)));
+        return ir.VectorOr(ir.VectorAnd(reg_n, reg_d), ir.VectorAndNot(reg_m, reg_d));
     });
 }
 
 bool TranslatorVisitor::asimd_VBIT(bool D, size_t Vn, size_t Vd, bool N, bool Q, bool M, size_t Vm) {
     return BitwiseInstruction<true>(*this, D, Vn, Vd, N, Q, M, Vm, [this](const auto& reg_d, const auto& reg_n, const auto& reg_m) {
-        return ir.VectorOr(ir.VectorAnd(reg_n, reg_m), ir.VectorAnd(reg_d, ir.VectorNot(reg_m)));
+        return ir.VectorOr(ir.VectorAnd(reg_n, reg_m), ir.VectorAndNot(reg_d, reg_m));
     });
 }
 
 bool TranslatorVisitor::asimd_VBIF(bool D, size_t Vn, size_t Vd, bool N, bool Q, bool M, size_t Vm) {
     return BitwiseInstruction<true>(*this, D, Vn, Vd, N, Q, M, Vm, [this](const auto& reg_d, const auto& reg_n, const auto& reg_m) {
-        return ir.VectorOr(ir.VectorAnd(reg_d, reg_m), ir.VectorAnd(reg_n, ir.VectorNot(reg_m)));
+        return ir.VectorOr(ir.VectorAnd(reg_d, reg_m), ir.VectorAndNot(reg_n, reg_m));
     });
 }
 
diff --git a/src/dynarmic/frontend/A32/translate/impl/asimd_two_regs_shift.cpp b/src/dynarmic/frontend/A32/translate/impl/asimd_two_regs_shift.cpp
index e5ea0e22..a8cf1b40 100644
--- a/src/dynarmic/frontend/A32/translate/impl/asimd_two_regs_shift.cpp
+++ b/src/dynarmic/frontend/A32/translate/impl/asimd_two_regs_shift.cpp
@@ -177,7 +177,7 @@ bool TranslatorVisitor::asimd_VSRI(bool D, size_t imm6, size_t Vd, bool L, bool
 
     const auto shifted = ir.VectorLogicalShiftRight(esize, reg_m, static_cast<u8>(shift_amount));
     const auto mask_vec = ir.VectorBroadcast(esize, I(esize, mask));
-    const auto result = ir.VectorOr(ir.VectorAnd(reg_d, ir.VectorNot(mask_vec)), shifted);
+    const auto result = ir.VectorOr(ir.VectorAndNot(reg_d, mask_vec), shifted);
 
     ir.SetVector(d, result);
     return true;
@@ -203,7 +203,7 @@ bool TranslatorVisitor::asimd_VSLI(bool D, size_t imm6, size_t Vd, bool L, bool
 
     const auto shifted = ir.VectorLogicalShiftLeft(esize, reg_m, static_cast<u8>(shift_amount));
     const auto mask_vec = ir.VectorBroadcast(esize, I(esize, mask));
-    const auto result = ir.VectorOr(ir.VectorAnd(reg_d, ir.VectorNot(mask_vec)), shifted);
+    const auto result = ir.VectorOr(ir.VectorAndNot(reg_d, mask_vec), shifted);
 
     ir.SetVector(d, result);
     return true;
diff --git a/src/dynarmic/frontend/A64/translate/impl/simd_crypto_four_register.cpp b/src/dynarmic/frontend/A64/translate/impl/simd_crypto_four_register.cpp
index 0e1bae79..8464bba5 100644
--- a/src/dynarmic/frontend/A64/translate/impl/simd_crypto_four_register.cpp
+++ b/src/dynarmic/frontend/A64/translate/impl/simd_crypto_four_register.cpp
@@ -23,7 +23,7 @@ bool TranslatorVisitor::BCAX(Vec Vm, Vec Va, Vec Vn, Vec Vd) {
     const IR::U128 m = ir.GetQ(Vm);
     const IR::U128 n = ir.GetQ(Vn);
 
-    const IR::U128 result = ir.VectorEor(n, ir.VectorAnd(m, ir.VectorNot(a)));
+    const IR::U128 result = ir.VectorEor(n, ir.VectorAndNot(m, a));
 
     ir.SetQ(Vd, result);
     return true;
diff --git a/src/dynarmic/frontend/A64/translate/impl/simd_shift_by_immediate.cpp b/src/dynarmic/frontend/A64/translate/impl/simd_shift_by_immediate.cpp
index 6ffc7f6d..f39ccd0f 100644
--- a/src/dynarmic/frontend/A64/translate/impl/simd_shift_by_immediate.cpp
+++ b/src/dynarmic/frontend/A64/translate/impl/simd_shift_by_immediate.cpp
@@ -350,7 +350,7 @@ bool TranslatorVisitor::SRI_2(bool Q, Imm<4> immh, Imm<3> immb, Vec Vn, Vec Vd)
 
     const IR::U128 shifted = ir.VectorLogicalShiftRight(esize, operand1, shift_amount);
     const IR::U128 mask_vec = ir.VectorBroadcast(esize, I(esize, mask));
-    const IR::U128 result = ir.VectorOr(ir.VectorAnd(operand2, ir.VectorNot(mask_vec)), shifted);
+    const IR::U128 result = ir.VectorOr(ir.VectorAndNot(operand2, mask_vec), shifted);
 
     V(datasize, Vd, result);
     return true;
@@ -376,7 +376,7 @@ bool TranslatorVisitor::SLI_2(bool Q, Imm<4> immh, Imm<3> immb, Vec Vn, Vec Vd)
 
     const IR::U128 shifted = ir.VectorLogicalShiftLeft(esize, operand1, shift_amount);
     const IR::U128 mask_vec = ir.VectorBroadcast(esize, I(esize, mask));
-    const IR::U128 result = ir.VectorOr(ir.VectorAnd(operand2, ir.VectorNot(mask_vec)), shifted);
+    const IR::U128 result = ir.VectorOr(ir.VectorAndNot(operand2, mask_vec), shifted);
 
     V(datasize, Vd, result);
     return true;
diff --git a/src/dynarmic/frontend/A64/translate/impl/simd_three_same.cpp b/src/dynarmic/frontend/A64/translate/impl/simd_three_same.cpp
index 34939c83..5bcf3c73 100644
--- a/src/dynarmic/frontend/A64/translate/impl/simd_three_same.cpp
+++ b/src/dynarmic/frontend/A64/translate/impl/simd_three_same.cpp
@@ -773,7 +773,7 @@ bool TranslatorVisitor::BIC_asimd_reg(bool Q, Vec Vm, Vec Vn, Vec Vd) {
     const IR::U128 operand1 = V(datasize, Vn);
     const IR::U128 operand2 = V(datasize, Vm);
 
-    IR::U128 result = ir.VectorAnd(operand1, ir.VectorNot(operand2));
+    IR::U128 result = ir.VectorAndNot(operand1, operand2);
     if (datasize == 64) {
         result = ir.VectorZeroUpper(result);
     }
diff --git a/src/dynarmic/ir/ir_emitter.cpp b/src/dynarmic/ir/ir_emitter.cpp
index 4f13c318..84f72203 100644
--- a/src/dynarmic/ir/ir_emitter.cpp
+++ b/src/dynarmic/ir/ir_emitter.cpp
@@ -958,6 +958,10 @@ U128 IREmitter::VectorAnd(const U128& a, const U128& b) {
     return Inst<U128>(Opcode::VectorAnd, a, b);
 }
 
+U128 IREmitter::VectorAndNot(const U128& a, const U128& b) {
+    return Inst<U128>(Opcode::VectorAndNot, a, b);
+}
+
 U128 IREmitter::VectorArithmeticShiftRight(size_t esize, const U128& a, u8 shift_amount) {
     switch (esize) {
     case 8:
diff --git a/src/dynarmic/ir/ir_emitter.h b/src/dynarmic/ir/ir_emitter.h
index f4cf66fd..2814f5ed 100644
--- a/src/dynarmic/ir/ir_emitter.h
+++ b/src/dynarmic/ir/ir_emitter.h
@@ -240,6 +240,7 @@ public:
     U128 VectorAbs(size_t esize, const U128& a);
     U128 VectorAdd(size_t esize, const U128& a, const U128& b);
     U128 VectorAnd(const U128& a, const U128& b);
+    U128 VectorAndNot(const U128& a, const U128& b);
     U128 VectorArithmeticShiftRight(size_t esize, const U128& a, u8 shift_amount);
     U128 VectorArithmeticVShift(size_t esize, const U128& a, const U128& b);
     U128 VectorBroadcast(size_t esize, const UAny& a);
diff --git a/src/dynarmic/ir/opcodes.inc b/src/dynarmic/ir/opcodes.inc
index 666f6fa0..57e4ba33 100644
--- a/src/dynarmic/ir/opcodes.inc
+++ b/src/dynarmic/ir/opcodes.inc
@@ -291,6 +291,7 @@ OPCODE(VectorAdd16,                                         U128,           U128
 OPCODE(VectorAdd32,                                         U128,           U128,           U128                                            )
 OPCODE(VectorAdd64,                                         U128,           U128,           U128                                            )
 OPCODE(VectorAnd,                                           U128,           U128,           U128                                            )
+OPCODE(VectorAndNot,                                        U128,           U128,           U128                                            )
 OPCODE(VectorArithmeticShiftRight8,                         U128,           U128,           U8                                              )
 OPCODE(VectorArithmeticShiftRight16,                        U128,           U128,           U8                                              )
 OPCODE(VectorArithmeticShiftRight32,                        U128,           U128,           U8                                              )